Spradling V, Awika J, Koutsos E, dierenfeld E. 2007. Determination of tannin levels in various plants and their possible effect on iron chelation in lemurs. In Ward A, Hunt A, Maslanka M, Eds. Proceedings of the Seventh Conference on Zoo and Wildlife Nutrition, AZA Nutrition Advisory Group, Knoxville, TN.
Lemurs are one of several species that can suffer from excess iron accumulation in tissues, termed hemosiderosis. The more severe form, hemochromatosis, develops when hemosiderosis is accompanied by functional or morphologic evidence of iron toxicity and may result in clinical disease and death. Organs most often affected include the liver, heart, spleen, and gastrointestinal tract. The pathology of this problem/disease is not entirely understood although it has been discussed by many scientists and veterinarians. Hemosiderin is deposited in multiple organs including the duodenum, stomach, jejunum, ileum, liver, spleen, kidney and lymph nodes. Excessive iron deposition can have toxic effects on parenchymal cells as well as hepatocytes. Histologic lesions reported in the liver include fibrosis, hepatocellular necrosis, distorted architecture, bile duct hyperplasia, hepatocellular adenoma, hepatocellular carcinoma, and cholangioma is also reported.Spradling – DETERMINATION OF TANNIN LEVELS IN VARIOUS PLANTS AND THEIR POSSIBLE EFFECT ON IRON CHELATION IN LEMURS.pdf     2 MB